Computational Chemistry Research Scientist (Computational Drug Design)

Job Description

• Conduct computational chemistry for hit/lead identification and optimization within computational drug design and drug discovery programs.
• Apply molecular modeling, cheminformatics, data science, physics-based methods, generative models, machine learning, and AI-enabled approaches to design new chemical entities.
• Collaborate with chemists, structural biologists, biologists, DMPK, Safety Assessment, and other interdisciplinary research groups to advance safe and efficacious drug candidates.
• Develop computational methodologies and workflows, share successful methods, and contribute to Vertex’s global computational chemistry and R&D capabilities.
• Requires a Ph.D. or equivalent degree in Computational Chemistry, 0–3 years of relevant employment experience, strong structure-based drug design expertise, Python/programming skills, and experience with modern AI computational capabilities.
• Full-time hybrid or on-site role in Boston, MA; hybrid work permits remote work up to two days per week. Salary: $108,000–$162,000, plus eligibility for annual bonus and equity awards.